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Instant Pot Mississippi Pot Roast

Make Mississippi Pot Roast in your Instant Pot for a tender, juicy and flavorful meal. This comforting, hearty dinner recipe will feed your whole family with minimal effort AND very little dishes!
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Course: Main Course
Cuisine: American
Keyword: how to make instant pot mississippi pot roast
Prep Time: 10 minutes
Cook Time: 1 hour 25 minutes
Servings: 8
Calories: 474kcal
Author: Megan Porta


  • Instant Pot


  • 3-4 lb chuck roast
  • 1 tsp salt
  • 1 tsp pepper
  • 1 tsp garlic powder
  • 1 tsp onion powder
  • 3 tbsp olive oil
  • 1 yellow onion chopped
  • 10 oz beef stock or broth
  • 16 oz pepperoncinis
  • 1/2 cup juice from the pepperoncini jar
  • 1 oz dry Ranch dressing mix (1 packet)
  • 1 oz Au Jus (1 packet)
  • 6 tbsp butter cut into 1-Tbsp chunks
  • 2 tbsp water
  • 2 tbsp cornstarch


  • Cut the roast into 3-4 chunks, trimming and discarding excess fat. In a small bowl, combine the salt, pepper, garlic powder and onion powder. Mix well and rub over all surfaces of beef chunks.
  • Set Instant Pot to saute. Heat the olive oil and add the pieces of beef to the pot. Cook for 2 minutes/side. Do this in batches, if needed, and transfer to a cutting board.
  • Add the onion and saute 3 minutes, or until fragrant. Add beef stock/broth and deglaze pot (scrape bits from the bottom of the pan with a spoon). Add the seared meat to pot, along with pepperoncinis, pepperoncini juice, both dry mixes and the butter. Cover and cook on high pressure (pressure cook setting) for 45 minutes. It will take the pot approximately 17 minutes to build up pressure before it begins cooking. Let the pressure release naturally for 10 minutes, then do a manual release.
  • Remove the beef from the pot and place on a cutting board. Shred meat using a fork.
  • Combine the water and cornstarch in a small bowl and mix. Set the pot to saute and bring the liquid to a boil. Whisk in the water-cornstarch mixture and let simmer until thick.
  • Add shredded meat back to the pot. Let sit 5 minutes. Serve with mashed potatoes or rice!


Calories: 474kcal | Carbohydrates: 9g | Protein: 35g | Fat: 34g | Saturated Fat: 15g | Cholesterol: 140mg | Sodium: 862mg | Potassium: 800mg | Fiber: 2g | Sugar: 2g | Vitamin A: 477IU | Vitamin C: 48mg | Calcium: 45mg | Iron: 4mg